4TVJ

HUMAN ARTD2 (PARP2) - CATALYTIC DOMAIN IN COMPLEX WITH OLAPARIB

Summary for 4TVJ

• Entry DOI: 10.2210/pdb4tvj/pdb
• Related: 3KCZ 3KJD
• Descriptor: Poly [ADP-ribose] polymerase 2, 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one, GLYCEROL, ... (4 entities in total)
• Functional Keywords: poly(adp-ribose) transferase, inhibitor, adp-ribosylation, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: Q9UGN5
• Total number of polymer chains: 2
• Total formula weight: 84801.05

Authors

Karlberg, T.,Thorsell, A.G.,Ekblad, T.,Pinto, A.F.,Schuler, H. (deposition date: 2014-06-27, release date: 2015-07-08, Last modification date: 2023-12-20)

• Primary citation: Thorsell, A.G.,Ekblad, T.,Karlberg, T.,Low, M.,Pinto, A.F.,Tresaugues, L.,Moche, M.,Cohen, M.S.,Schuler, H.; Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.; J. Med. Chem., 60:1262-1271, 2017; PubMed: 28001384; DOI: 10.1021/acs.jmedchem.6b00990

Experimental method

X-RAY DIFFRACTION (2.1 Å)