4TVJ

HUMAN ARTD2 (PARP2) - CATALYTIC DOMAIN IN COMPLEX WITH OLAPARIB

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Poly [ADP-ribose] polymerase 2	polymer	368	41827.9	2	UniProt (Q9UGN5) Pfam (PF02877) Pfam (PF00644)	Homo sapiens (Human)	hPARP-2,ADP-ribosyltransferase diphtheria toxin-like 2,ARTD2,NAD(+) ADP-ribosyltransferase 2,ADPRT-2,Poly[ADP-ribose] synthase 2,pADPRT-2
2	C, F (A, B)	4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one	non-polymer		434.5	2	Chemie (09L)
3	D, E, G (A, B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
4	H, I (A, B)	water	water		18.0	267	Chemie (HOH)

Sequence modifications

A, B: 235 - 579 (UniProt: Q9UGN5)

PDB	External Database	Details
Met 212	-	initiating methionine
His 213	-	expression tag
His 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag
Ser 219	-	expression tag
Ser 220	-	expression tag
Gly 221	-	expression tag
Val 222	-	expression tag
Asp 223	-	expression tag
Leu 224	-	expression tag
Gly 225	-	expression tag
Thr 226	-	expression tag
Glu 227	-	expression tag
Asn 228	-	expression tag
Leu 229	-	expression tag
Tyr 230	-	expression tag
Phe 231	-	expression tag
Gln 232	-	expression tag
Ser 233	-	expression tag
Met 234	-	expression tag
His 447	Pro 447	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	83655.8
Non-Polymers*	Number of molecules	5
	Total formula weight	1145.2
All*	Total formula weight	84801.1

*Water molecules are not included.