4TUU
Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design
Summary for 4TUU
| Entry DOI | 10.2210/pdb4tuu/pdb |
| Related | 4TV3 |
| Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (2 entities in total) |
| Functional Keywords | lipid kinase activity, atpase activity, surface plasmon resonance (spr), isothermal titration calorimetry (itc)., transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 109983.09 |
| Authors | Chen, P.,Deng, Y.-L.,Bergqvist, S.,Falk, M.,Liu, W.,Timofeevski, S. (deposition date: 2014-06-24, release date: 2014-08-06, Last modification date: 2023-12-27) |
| Primary citation | Chen, P.,Deng, Y.L.,Bergqvist, S.,Falk, M.D.,Liu, W.,Timofeevski, S.,Brooun, A. Engineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design. Protein Sci., 23:1332-1340, 2014 Cited by PubMed: 25043846DOI: 10.1002/pro.2517 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.64 Å) |
Structure validation
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