4TUU

Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design

4TUU の概要

• エントリーDOI: 10.2210/pdb4tuu/pdb
• 関連するPDBエントリー: 4TV3
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (2 entities in total)
• 機能のキーワード: lipid kinase activity, atpase activity, surface plasmon resonance (spr), isothermal titration calorimetry (itc)., transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 109983.09

構造登録者

Chen, P.,Deng, Y.-L.,Bergqvist, S.,Falk, M.,Liu, W.,Timofeevski, S. (登録日: 2014-06-24, 公開日: 2014-08-06, 最終更新日: 2023-12-27)

• 主引用文献: Chen, P.,Deng, Y.L.,Bergqvist, S.,Falk, M.D.,Liu, W.,Timofeevski, S.,Brooun, A.; Engineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design.; Protein Sci., 23:1332-1340, 2014; PubMed: 25043846; DOI: 10.1002/pro.2517

実験手法

X-RAY DIFFRACTION (2.64 Å)