4TTS

Crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase (Y200A) complex with 10-formyl-5,8-dideazafolate

4TTS の概要

• エントリーDOI: 10.2210/pdb4tts/pdb
• 関連するPDBエントリー: 4QPC 4QPD 4TS4 4TT8
• 分子名称: 10-formyltetrahydrofolate dehydrogenase, N-(4-{[(2-amino-4-hydroxyquinazolin-6-yl)methyl](formyl)amino}benzoyl)-L-glutamic acid (3 entities in total)
• 機能のキーワード: 10-formyltetrahydrofolate dehydrogenase, hydrolase domain, catalysis, oxidoreductase
• 由来する生物種: Danio rerio (Zebrafish)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35831.77

構造登録者

Lin, C.C.,Chen, C.J.,Fu, T.F.,Chuankhayan, P.,Kao, T.T.,Chang, W.N. (登録日: 2014-06-23, 公開日: 2015-04-15, 最終更新日: 2023-11-08)

• 主引用文献: Lin, C.C.,Chuankhayan, P.,Chang, W.N.,Kao, T.T.,Guan, H.H.,Fun, H.K.,Nakagawa, A.,Fu, T.F.,Chen, C.J.; Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition.; Acta Crystallogr.,Sect.D, 71:1006-1021, 2015; PubMed: 25849409; DOI: 10.1107/S1399004715002928

実験手法

X-RAY DIFFRACTION (2 Å)