4TTS

Crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase (Y200A) complex with 10-formyl-5,8-dideazafolate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	10-formyltetrahydrofolate dehydrogenase	polymer	318	35364.3	1	UniProt (E3NZ06) Pfam (PF00551) Pfam (PF02911) In PDB	Danio rerio (Zebrafish)
2	A	N-(4-{[(2-amino-4-hydroxyquinazolin-6-yl)methyl](formyl)amino}benzoyl)-L-glutamic acid	non-polymer		467.4	1	Chemie (6DD)
3		water	water		18.0	288	Chemie (HOH)

Sequence modifications

A: 1 - 311 (UniProt: E3NZ06)

PDB	External Database	Details
Ala 200	Tyr 200	engineered mutation
Glu 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag
His 315	-	expression tag
His 316	-	expression tag
His 317	-	expression tag
His 318	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35364.3
Non-Polymers*	Number of molecules	1
	Total formula weight	467.4
All*	Total formula weight	35831.8

*Water molecules are not included.