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4TRO

Structure of the enoyl-ACP reductase of Mycobacterium tuberculosis InhA, inhibited with the active metabolite of isoniazid

Summary for 4TRO
Entry DOI10.2210/pdb4tro/pdb
Related4TRM 4TRN
DescriptorEnoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDE, ... (7 entities in total)
Functional Keywordsisoniazid, oxidoreductase
Biological sourceMycobacterium tuberculosis
Total number of polymer chains1
Total formula weight30821.85
Authors
Chollet, A.,Julien, S.,Mourey, L.,Maveyraud, L. (deposition date: 2014-06-17, release date: 2015-04-29, Last modification date: 2023-12-20)
Primary citationChollet, A.,Mourey, L.,Lherbet, C.,Delbot, A.,Julien, S.,Baltas, M.,Bernadou, J.,Pratviel, G.,Maveyraud, L.,Bernardes-Genisson, V.
Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach.
J.Struct.Biol., 190:328-337, 2015
Cited by
PubMed: 25891098
DOI: 10.1016/j.jsb.2015.04.008
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.4 Å)
Structure validation

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