4TQP

Human transthyretin (TTR) complexed with (R)-3-(9H-fluoren-9-ylideneaminooxy)-2-methyl-N-(methylsulfonyl) propionamide in a dual binding mode

4TQP の概要

• エントリーDOI: 10.2210/pdb4tqp/pdb
• 関連するPDBエントリー: 4TQ8 4TQH 4TQI
• 分子名称: Transthyretin, (2R)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methyl-N-(methylsulfonyl)propanamide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: polyethylene glycol ttr crystallization, forward and reverse binding modes, amyloid antagonist inhibitor, transthyretin, fluorenone based inhibitors, hormone
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted: P02766
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28455.73

構造登録者

Ciccone, L.,Nencetti, S.,Rossello, A.,Orlandini, E.,Stura, E.A. (登録日: 2014-06-11, 公開日: 2015-06-24, 最終更新日: 2023-09-27)

• 主引用文献: Ciccone, L.,Nencetti, S.,Rossello, A.,Tepshi, L.,Stura, E.A.,Orlandini, E.; X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors.; J Enzyme Inhib Med Chem, :1-10, 2015; PubMed: 26235916

実験手法

X-RAY DIFFRACTION (1.58 Å)