4TQH
Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)ethanoic acid
Summary for 4TQH
Entry DOI | 10.2210/pdb4tqh/pdb |
Related | 3GS0 3GS4 4TQ8 4TQI 4TQP |
Descriptor | Transthyretin, [(9H-fluoren-9-ylideneamino)oxy]acetic acid, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | transthyretin (ttr) complex, amyloid antagonist and inhibitor, fluorenone based inhibitor, dual binding mode, hormone |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28123.29 |
Authors | Ciccone, L.,Nencetti, S.,Rossello, A.,Orlandini, E.,Stura, E.A. (deposition date: 2014-06-11, release date: 2015-06-24, Last modification date: 2023-09-27) |
Primary citation | Ciccone, L.,Nencetti, S.,Rossello, A.,Tepshi, L.,Stura, E.A.,Orlandini, E. X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, :1-10, 2015 Cited by PubMed: 26235916PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.511 Å) |
Structure validation
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