4TQB

The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

4TQB の概要

• エントリーDOI: 10.2210/pdb4tqb/pdb
• 関連するPDBエントリー: 4TPW 4TQC
• 分子名称: Eukaryotic translation initiation factor 4E, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, (2E)-2-{2-[4-(4-bromophenyl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid, ... (5 entities in total)
• 機能のキーワード: eif4e, translation initiation inhibitor, allosteric, 4egi1, protein binding
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, P-body: P06730
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46315.64

構造登録者

Papadopoulos, E.,Jenni, S.,Wagner, G. (登録日: 2014-06-10, 公開日: 2014-08-13, 最終更新日: 2023-12-27)

• 主引用文献: Papadopoulos, E.,Jenni, S.,Kabha, E.,Takrouri, K.J.,Yi, T.,Salvi, N.,Luna, R.E.,Gavathiotis, E.,Mahalingam, P.,Arthanari, H.,Rodriguez-Mias, R.,Yefidoff-Freedman, R.,Aktas, B.H.,Chorev, M.,Halperin, J.A.,Wagner, G.; Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.; Proc.Natl.Acad.Sci.USA, 111:E3187-E3195, 2014; PubMed: 25049413; DOI: 10.1073/pnas.1410250111

実験手法

X-RAY DIFFRACTION (1.59 Å)