4TOT

Crystal structure of rat cyclophilin D in complex with a potent nonimmunosuppressive inhibitor

Summary for 4TOT

• Entry DOI: 10.2210/pdb4tot/pdb
• Related PRD ID: PRD_002115
• Descriptor: Peptidyl-prolyl cis-trans isomerase F, mitochondrial, nonimmunosuppressive inhibitor, HEXAETHYLENE GLYCOL, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, cyclosporin, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Mitochondrion matrix : P29117
• Total number of polymer chains: 8
• Total formula weight: 77541.41

Authors

Knapp, M.S.,Elling, R.A. (deposition date: 2014-06-06, release date: 2014-11-12, Last modification date: 2024-04-03)

• Primary citation: Fu, J.,Tjandra, M.,Becker, C.,Bednarczyk, D.,Capparelli, M.,Elling, R.,Hanna, I.,Fujimoto, R.,Furegati, M.,Karur, S.,Kasprzyk, T.,Knapp, M.,Leung, K.,Li, X.,Lu, P.,Mergo, W.,Miault, C.,Ng, S.,Parker, D.,Peng, Y.,Roggo, S.,Rivkin, A.,Simmons, R.L.,Wang, M.,Wiedmann, B.,Weiss, A.H.,Xiao, L.,Xie, L.,Xu, W.,Yifru, A.,Yang, S.,Zhou, B.,Sweeney, Z.K.; Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.; J.Med.Chem., 57:8503-8516, 2014; PubMed: 25310383; DOI: 10.1021/jm500862r

Experimental method

X-RAY DIFFRACTION (2.39 Å)