4TOT
Crystal structure of rat cyclophilin D in complex with a potent nonimmunosuppressive inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Peptidyl-prolyl cis-trans isomerase F, mitochondrial | polymer | 165 | 17692.2 | 4 | UniProt (P29117) Pfam (PF00160) | Rattus norvegicus (Rat) | PPIase F,Cyclophilin D,CypD,Cyclophilin F,Rotamase F |
| 2 | E, F, G, H (E, F, G, H) | nonimmunosuppressive inhibitor | polymer | 11 | 1362.8 | 4 | BIRD (PRD_002115) | synthetic construct | |
| 3 | I, K, M, N (A, B, C, D) | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 4 | Chemie (P6G) | |||
| 4 | J, L (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | O, P, Q, R, S... (A, B, C, D, E...) | water | water | 18.0 | 298 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 165 (UniProt: P29117)
| PDB | External Database | Details |
|---|---|---|
| Ala 1 | - | expression tag |
| Ile 133 | Lys 174 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 76220.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1321.5 | |
| All* | Total formula weight | 77541.4 |
