4TOR
Crystal structure of Tankyrase 1 with IWR-8
Summary for 4TOR
Entry DOI | 10.2210/pdb4tor/pdb |
Related | 4TOS |
Descriptor | Tankyrase-1, ZINC ION, 1-[(1-acetyl-5-bromo-1H-indol-6-yl)sulfonyl]-N-ethyl-N-(3-methylphenyl)piperidine-4-carboxamide, ... (5 entities in total) |
Functional Keywords | transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 110748.52 |
Authors | |
Primary citation | Kulak, O.,Chen, H.,Holohan, B.,Wu, X.,He, H.,Borek, D.,Otwinowski, Z.,Yamaguchi, K.,Garofalo, L.A.,Ma, Z.,Wright, W.,Chen, C.,Shay, J.W.,Zhang, X.,Lum, L. Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Mol.Cell.Biol., 35:2425-2435, 2015 Cited by PubMed: 25939383DOI: 10.1128/MCB.00392-15 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.501 Å) |
Structure validation
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