4TO5

Structure basis of cellular dNTP regulation, SAMHD1-GTP-dTTP-dCTP complex

Summary for 4TO5

Entry DOI	10.2210/pdb4to5/pdb
Related	4TNP 4TNQ 4TNR 4TNX 4TNY 4TNZ 4TO0 4TO1 4TO2 4TO3 4TO4 4TO6
Descriptor	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
Functional Keywords	samhd1, hiv, restriction factor, dntpase, dntp regulation, host pathogen interaction, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q9Y3Z3
Total number of polymer chains	4
Total formula weight	244403.93
Authors	Ji, X.,Tang, C.,Zhao, Q.,Wang, W.,Xiong, Y. (deposition date: 2014-06-05, release date: 2014-10-01, Last modification date: 2023-09-27)
Primary citation	Ji, X.,Tang, C.,Zhao, Q.,Wang, W.,Xiong, Y. Structural basis of cellular dNTP regulation by SAMHD1. Proc.Natl.Acad.Sci.USA, 111:E4305-E4314, 2014 Cited by PubMed: 25267621 DOI: 10.1073/pnas.1412289111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation