4TO5
Structure basis of cellular dNTP regulation, SAMHD1-GTP-dTTP-dCTP complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, D, B | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 514 | 59604.2 | 4 | UniProt (Q9Y3Z3) Pfam (PF01966) In PDB | Homo sapiens (Human) | dNTPase,Dendritic cell-derived IFNG-induced protein,DCIP,Monocyte protein 5,MOP-5,SAM domain and HD domain-containing protein 1 |
| 2 | A, C, D, B | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE | non-polymer | 467.2 | 4 | Chemie (DCP) | |||
| 3 | A, D, B | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 4 | Chemie (GTP) | |||
| 4 | A, C, D, B | THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 482.2 | 4 | Chemie (TTP) | |||
| 5 | A, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 6 | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, C, D, B: 113 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Arg 206 | His 206 | engineered mutation |
| Asn 207 | Asp 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 238416.7 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 5987.2 | |
| All* | Total formula weight | 244403.9 |
