4TO1

Structure basis of cellular dNTP regulation, SAMHD1-GTP-dATP/dCTP-dCTP complex

Summary for 4TO1

• Entry DOI: 10.2210/pdb4to1/pdb
• Related: 4TNP 4TNQ 4TNR 4TNX 4TNY 4TNZ 4TO0 4TO2 4TO3 4TO4 4TO5 4TO6
• Descriptor: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: samhd1, hiv, restriction factor, dntpase, dntp regulation, host pathogen interaction, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q9Y3Z3
• Total number of polymer chains: 4
• Total formula weight: 244391.93

Authors

Ji, X.,Tang, C.,Zhao, Q.,Wang, W.,Xiong, Y. (deposition date: 2014-06-05, release date: 2014-10-01, Last modification date: 2023-09-27)

• Primary citation: Ji, X.,Tang, C.,Zhao, Q.,Wang, W.,Xiong, Y.; Structural basis of cellular dNTP regulation by SAMHD1.; Proc.Natl.Acad.Sci.USA, 111:E4305-E4314, 2014; PubMed: 25267621; DOI: 10.1073/pnas.1412289111

Experimental method

X-RAY DIFFRACTION (2.55 Å)