4S3N

Crystal structure of human OAS3 domain I in complex with dsRNA

Summary for 4S3N

• Entry DOI: 10.2210/pdb4s3n/pdb
• Related: 1PX5 4IG8
• Descriptor: 2'-5'-oligoadenylate synthase 3, RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3'), RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3'), ... (4 entities in total)
• Functional Keywords: transferase, dsrna, transferase-rna complex, oas, oas1, oas2, oas3, oasl, 2-5a, rnase l, transferase/rna
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q9Y6K5
• Total number of polymer chains: 3
• Total formula weight: 53385.66

Authors

Donovan, J.,Whitney, G.,Rath, S.,Korennykh, A. (deposition date: 2015-02-26, release date: 2015-03-25, Last modification date: 2023-09-20)

• Primary citation: Donovan, J.,Whitney, G.,Rath, S.,Korennykh, A.; Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3.; Proc.Natl.Acad.Sci.USA, 112:3949-3954, 2015; PubMed: 25775560; DOI: 10.1073/pnas.1419409112

Experimental method

X-RAY DIFFRACTION (2 Å)