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4S3N

Crystal structure of human OAS3 domain I in complex with dsRNA

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
2'-5'-oligoadenylate synthase 3polymer37341298.41UniProt (Q9Y6K5)
Pfam (PF10421)
Homo sapiens (human)(2-5')oligo(A) synthase 3, 2-5A synthase 3, p100 OAS, p100OAS
2B
(B)
RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3')polymer196017.61synthetic
3C
(C)
RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3')polymer196069.71synthetic
4D, E, F
(A, B, C)
waterwater18.0292Chemie (HOH)
Sequence modifications
A: 1 - 371 (UniProt: Q9Y6K5)
PDBExternal DatabaseDetails
Gly -1-expression tag
Pro 0-expression tag
Lys 18Arg 18variant
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight53385.7
All*Total formula weight53385.7
*Water molecules are not included.

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PDB entries from 2025-06-11

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