4S18
The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and oxaliplatin
Summary for 4S18
Entry DOI | 10.2210/pdb4s18/pdb |
Related | 4OT4 4S0Q |
Descriptor | Ribonuclease pancreatic, CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II) (3 entities in total) |
Functional Keywords | ribonuclease fold, cleavage of rna, rna, bovine pancreas, hydrolase |
Biological source | Bos taurus (bovine,cow,domestic cattle,domestic cow) |
Cellular location | Secreted: P61823 |
Total number of polymer chains | 2 |
Total formula weight | 29272.25 |
Authors | Merlino, A. (deposition date: 2015-01-09, release date: 2015-11-25, Last modification date: 2023-09-20) |
Primary citation | Messori, L.,Marzo, T.,Merlino, A. Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts. J.Inorg.Biochem., 153:136-142, 2015 Cited by PubMed: 26239545DOI: 10.1016/j.jinorgbio.2015.07.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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