4S18

The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and oxaliplatin

Summary for 4S18

Entry DOI	10.2210/pdb4s18/pdb
Related	4OT4 4S0Q
Descriptor	Ribonuclease pancreatic, CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II) (3 entities in total)
Functional Keywords	ribonuclease fold, cleavage of rna, rna, bovine pancreas, hydrolase
Biological source	Bos taurus (bovine,cow,domestic cattle,domestic cow)
Cellular location	Secreted: P61823
Total number of polymer chains	2
Total formula weight	29272.25
Authors	Merlino, A. (deposition date: 2015-01-09, release date: 2015-11-25, Last modification date: 2023-09-20)
Primary citation	Messori, L.,Marzo, T.,Merlino, A. Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts. J.Inorg.Biochem., 153:136-142, 2015 Cited by PubMed: 26239545 DOI: 10.1016/j.jinorgbio.2015.07.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.27 Å)

Structure validation