4RZ1

RENIN IN COMPLEXED WITH (3S,4S)-4-({[4-methoxy-3-(3-methoxypropoxy)benzoyl](propan-2-yl)amino}methyl)pyrrolidin-3-yl benzylcarbamate INHIBITOR

Summary for 4RZ1

• Entry DOI: 10.2210/pdb4rz1/pdb
• Descriptor: Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, (3S,4S)-4-({[4-methoxy-3-(3-methoxypropoxy)benzoyl](propan-2-yl)amino}methyl)pyrrolidin-3-yl benzylcarbamate, ... (6 entities in total)
• Functional Keywords: hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens
• Cellular location: Secreted: P00797
• Total number of polymer chains: 2
• Total formula weight: 76256.01

Authors

Ostermann, N. (deposition date: 2014-12-18, release date: 2015-03-25, Last modification date: 2020-07-29)

• Primary citation: Sellner, H.,Cottens, S.,Cumin, F.,Ehrhardt, C.,Kosaka, T.,Lorthiois, E.,Ostermann, N.,Webb, R.L.,Rigel, D.F.,Wagner, T.,Maibaum, J.; trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: Prime site exploration using an oxygen linker.; Bioorg.Med.Chem.Lett., 25:1787-1791, 2015; PubMed: 25754490; DOI: 10.1016/j.bmcl.2015.02.040

Experimental method

X-RAY DIFFRACTION (2.6 Å)