4RY5
C-terminal mutant (W550N) of HCV/J4 RNA polymerase
Summary for 4RY5
Entry DOI | 10.2210/pdb4ry5/pdb |
Related | 1NB4 4RY4 4RY6 4RY7 |
Descriptor | HCV J4 RNA polymerase (NS5B), MANGANESE (II) ION, URIDINE 5'-TRIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | hepatitis c virus, replication, function analysis, viral rna polymerase, rdrp, rna rntp mg, nucleotide transfer, transferase |
Biological source | Hepatitis C virus isolate HC-J4 (HCV) |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972 |
Total number of polymer chains | 2 |
Total formula weight | 127957.30 |
Authors | Jaeger, J.,Cherry, A.,Dennis, C. (deposition date: 2014-12-13, release date: 2014-12-31, Last modification date: 2023-09-20) |
Primary citation | Cherry, A.L.,Dennis, C.A.,Baron, A.,Eisele, L.E.,Thommes, P.A.,Jaeger, J. Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation. J.Virol., 89:2052-2063, 2015 Cited by PubMed: 25428878DOI: 10.1128/JVI.01106-14 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.71 Å) |
Structure validation
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