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4RY5

C-terminal mutant (W550N) of HCV/J4 RNA polymerase

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MN A 1001
ChainResidue
AASP220
AASP318
AASP319
AUTP1003

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MN A 1002
ChainResidue
AASP220
ATHR221
AASP318
AUTP1003

site_idAC3
Number of Residues22
DetailsBINDING SITE FOR RESIDUE UTP A 1003
ChainResidue
AARG158
ALEU159
AILE160
AASP220
ATHR221
AARG222
ACYS223
APHE224
AASP225
ASER282
ATHR287
AASN291
AASP318
AASP319
ASER556
AMN1001
AMN1002
AHOH1209
AHOH1221
AHOH1270
AHOH1306
ALYS141

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN B 1001
ChainResidue
BASP220
BASP318
BASP319
BUTP1003
BHOH1188

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MN B 1002
ChainResidue
BASP220
BTHR221
BASP318
BUTP1003

site_idAC6
Number of Residues22
DetailsBINDING SITE FOR RESIDUE UTP B 1003
ChainResidue
BLYS141
BARG158
BLEU159
BILE160
BASP220
BTHR221
BARG222
BCYS223
BPHE224
BASP225
BSER282
BASP318
BASP319
BSER556
BGLY557
BMN1001
BMN1002
BHOH1165
BHOH1183
BHOH1188
BHOH1211
BHOH1255

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P26663
ChainResidueDetails
AASP220
AASP318
AASP319
BASP220
BASP318
BASP319

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ASER29
ASER42
BSER29
BSER42

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PDB entries from 2024-11-13

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