4RY5
C-terminal mutant (W550N) of HCV/J4 RNA polymerase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HCV J4 RNA polymerase (NS5B) | polymer | 570 | 63384.6 | 2 | UniProt (O92972) Pfam (PF00998) | Hepatitis C virus isolate HC-J4 (HCV) | RNA-dependent RNA polymerase |
| 2 | C, D, F, G (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 3 | E, H (A, B) | URIDINE 5'-TRIPHOSPHATE | non-polymer | 484.1 | 2 | Chemie (UTP) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 424 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 570 (UniProt: O92972)
| PDB | External Database | Details |
|---|---|---|
| Asn 550 | Trp 2969 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 126769.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1188.0 | |
| All* | Total formula weight | 127957.3 |
