4RX9

SYK Catalytic Domain Complexed with a Potent Pyrimidine Inhibitor

Summary for 4RX9

• Entry DOI: 10.2210/pdb4rx9/pdb
• Related: 4RX7 4RX8
• Descriptor: Tyrosine-protein kinase SYK, GLYCEROL, 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide, ... (4 entities in total)
• Functional Keywords: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane : P43405
• Total number of polymer chains: 1
• Total formula weight: 34293.45

Authors

Lee, C.C. (deposition date: 2014-12-09, release date: 2015-03-18, Last modification date: 2024-02-28)

• Primary citation: Thoma, G.,Smith, A.B.,van Eis, M.J.,Vangrevelinghe, E.,Blanz, J.,Aichholz, R.,Littlewood-Evans, A.,Lee, C.C.,Liu, H.,Zerwes, H.G.; Discovery and profiling of a selective and efficacious syk inhibitor.; J.Med.Chem., 58:1950-1963, 2015; PubMed: 25633741; DOI: 10.1021/jm5018863

Experimental method

X-RAY DIFFRACTION (1.75 Å)