4RX9
SYK Catalytic Domain Complexed with a Potent Pyrimidine Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase SYK | polymer | 290 | 33807.9 | 1 | UniProt (P43405) Pfam (PF07714) | Homo sapiens (human) | Spleen tyrosine kinase, p72-Syk |
| 2 | B (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | C (A) | 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide | non-polymer | 393.4 | 1 | Chemie (3YT) | |||
| 4 | D (A) | water | water | 18.0 | 204 | Chemie (HOH) |
Sequence modifications
A: 356 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| Met 353 | - | expression tag |
| Ala 354 | - | expression tag |
| Leu 355 | - | expression tag |
| Thr 467 | Lys 467 | conflict |
| His 636 | - | expression tag |
| His 637 | - | expression tag |
| His 638 | - | expression tag |
| His 639 | - | expression tag |
| His 640 | - | expression tag |
| His 641 | - | expression tag |
| His 642 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33807.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 485.5 | |
| All* | Total formula weight | 34293.4 |
