4RX7
SYK Catalytic Domain Complexed with a Potent Triazine Inhibitor
Summary for 4RX7
| Entry DOI | 10.2210/pdb4rx7/pdb |
| Related | 4RX8 4RX9 |
| Descriptor | Tyrosine-protein kinase SYK, FORMIC ACID, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cell membrane : P43405 |
| Total number of polymer chains | 1 |
| Total formula weight | 34202.32 |
| Authors | Lee, C.C. (deposition date: 2014-12-09, release date: 2015-03-18, Last modification date: 2024-02-28) |
| Primary citation | Thoma, G.,Smith, A.B.,van Eis, M.J.,Vangrevelinghe, E.,Blanz, J.,Aichholz, R.,Littlewood-Evans, A.,Lee, C.C.,Liu, H.,Zerwes, H.G. Discovery and profiling of a selective and efficacious syk inhibitor. J.Med.Chem., 58:1950-1963, 2015 Cited by PubMed: 25633741DOI: 10.1021/jm5018863 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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