4RX7
SYK Catalytic Domain Complexed with a Potent Triazine Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase SYK | polymer | 289 | 33669.8 | 1 | UniProt (P43405) Pfam (PF07714) In PDB | Homo sapiens (human) | Spleen tyrosine kinase, p72-Syk |
| 2 | A | FORMIC ACID | non-polymer | 46.0 | 1 | Chemie (FMT) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | A | 3-{[(1R,2S)-2-aminocyclohexyl]amino}-5-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}-1,2,4-triazine-6-carboxamide | non-polymer | 394.4 | 1 | Chemie (3YV) | |||
| 5 | water | water | 18.0 | 164 | Chemie (HOH) |
Sequence modifications
A: 356 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| Met 353 | - | expression tag |
| Ala 354 | - | expression tag |
| Leu 355 | - | expression tag |
| Thr 467 | Lys 467 | conflict |
| His 636 | - | expression tag |
| His 637 | - | expression tag |
| His 638 | - | expression tag |
| His 639 | - | expression tag |
| His 640 | - | expression tag |
| His 641 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33669.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 532.6 | |
| All* | Total formula weight | 34202.3 |
