4RWJ
Crystal Structure of FGFR1 (C488A, C584S) in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE)
Summary for 4RWJ
Entry DOI | 10.2210/pdb4rwj/pdb |
Related | 4RWI 4RWK 4RWL |
Descriptor | Fibroblast growth factor receptor 1, N-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide (3 entities in total) |
Functional Keywords | receptor tyrosine kinase, kinase, proto-oncogene, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P11362 |
Total number of polymer chains | 2 |
Total formula weight | 73380.35 |
Authors | Sohl, C.D.,Anderson, K.S. (deposition date: 2014-12-04, release date: 2015-04-22, Last modification date: 2023-09-20) |
Primary citation | Sohl, C.D.,Ryan, M.R.,Luo, B.,Frey, K.M.,Anderson, K.S. Illuminating the Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance for the FGFR1 Gatekeeper Mutation: The Achilles' Heel of Targeted Therapy. Acs Chem.Biol., 10:1319-1329, 2015 Cited by PubMed: 25686244DOI: 10.1021/acschembio.5b00014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.489 Å) |
Structure validation
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