4RWJ
Crystal Structure of FGFR1 (C488A, C584S) in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Fibroblast growth factor receptor 1 | polymer | 317 | 36226.6 | 2 | UniProt (P11362) Pfam (PF07714) In PDB | Homo sapiens (human) | FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr |
2 | A, B | N-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide | non-polymer | 463.6 | 2 | Chemie (66T) | |||
3 | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A, B: 458 - 765 (UniProt: P11362)
PDB | External Database | Details |
---|---|---|
Met 449 | - | expression tag |
Gly 450 | - | expression tag |
His 451 | - | expression tag |
His 452 | - | expression tag |
His 453 | - | expression tag |
His 454 | - | expression tag |
His 455 | - | expression tag |
His 456 | - | expression tag |
Met 457 | - | expression tag |
Ala 488 | Cys 488 | engineered mutation |
Ser 584 | Cys 584 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 72453.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 927.1 | |
All* | Total formula weight | 73380.3 |