4RT3

Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP

Summary for 4RT3

• Entry DOI: 10.2210/pdb4rt3/pdb
• Related: 4RT2
• Descriptor: DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'), ... (9 entities in total)
• Functional Keywords: dna polymerase beta, ternary complex, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 48354.72

Authors

Batra, V.K.,Wilson, S.H. (deposition date: 2014-11-12, release date: 2015-07-01, Last modification date: 2023-09-20)

• Primary citation: Kadina, A.P.,Kashemirov, B.A.,Oertell, K.,Batra, V.K.,Wilson, S.H.,Goodman, M.F.,McKenna, C.E.; Two Scaffolds from Two Flips: (alpha, beta)/(beta, gamma) CH2/NH "Met-Im" Analogues of dTTP.; Org.Lett., 17:2586-2589, 2015; PubMed: 25970636; DOI: 10.1021/acs.orglett.5b00799

Experimental method

X-RAY DIFFRACTION (1.92 Å)