4RSZ

The X-ray structure of the Primary Adduct formed in the Reaction between Cisplatin and Cytochrome c

Summary for 4RSZ

Entry DOI	10.2210/pdb4rsz/pdb
Descriptor	Cytochrome c, HEME C, Cisplatin, ... (6 entities in total)
Functional Keywords	electron transport
Biological source	Equus caballus (domestic horse,equine)
Cellular location	Mitochondrion intermembrane space: P00004
Total number of polymer chains	6
Total formula weight	76749.04
Authors	Merlino, A. (deposition date: 2014-11-12, release date: 2015-01-14, Last modification date: 2024-10-30)
Primary citation	Ferraro, G.,Messori, L.,Merlino, A. The X-ray structure of the primary adducts formed in the reaction between cisplatin and cytochrome c. Chem.Commun.(Camb.), 51:2559-2561, 2015 Cited by PubMed Abstract: In the present study, the interactions between cisplatin and cytochrome c are investigated. Based on high-resolution X-ray diffraction data, two monometalated species, i.e. cyt c-Pt(NH3)2 and cyt c-Pt(NH3)2Cl, are found to be the main adducts that form in the reaction between the protein and the drug. Both monodentate and bidentate platinum coordination to the protein is observed, with platinum binding either to Met65 or to Met65 and Glu61, simultaneously. PubMed: 25567806 DOI: 10.1039/c4cc09056j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation