4RSS
Crystal structure of tyrosine-protein kinase SYK with an inhibitor
Summary for 4RSS
Entry DOI | 10.2210/pdb4rss/pdb |
Descriptor | Tyrosine-protein kinase SYK, 1-[(3-methyl-1-{2-[(1,2,3-trimethyl-1H-indol-5-yl)amino]pyrimidin-4-yl}-1H-pyrazol-4-yl)methyl]azetidin-3-ol (3 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane : P43405 |
Total number of polymer chains | 1 |
Total formula weight | 34318.47 |
Authors | Lee, B.I.,Lee, S.J.,Choi, J.-S. (deposition date: 2014-11-11, release date: 2015-10-21, Last modification date: 2024-03-20) |
Primary citation | Choi, J.S.,Hwang, H.J.,Kim, S.W.,Lee, B.I.,Lee, J.,Song, H.J.,Koh, J.S.,Kim, J.H.,Lee, P.H. Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors. Bioorg.Med.Chem.Lett., 25:4441-4446, 2015 Cited by PubMed: 26384287DOI: 10.1016/j.bmcl.2015.09.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
Download full validation report