4RQQ
Crystal structure of human Fab PGDM1400, a broadly reactive and potent HIV-1 neutralizing antibody
Summary for 4RQQ
Entry DOI | 10.2210/pdb4rqq/pdb |
Related | 3U1S |
Descriptor | Human anti-HIV-1 antibody PGDM1400 light chain, Human anti-HIV-1 antibody PGDM1400 heavy chain (2 entities in total) |
Functional Keywords | igg, anti-hiv-1 antibody, hiv-1 env trimer, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 6 |
Total formula weight | 151600.06 |
Authors | Julien, J.-P.,Wilson, I.A. (deposition date: 2014-11-04, release date: 2014-11-19, Last modification date: 2023-12-06) |
Primary citation | Sok, D.,van Gils, M.J.,Pauthner, M.,Julien, J.P.,Saye-Francisco, K.L.,Hsueh, J.,Briney, B.,Lee, J.H.,Le, K.M.,Lee, P.S.,Hua, Y.,Seaman, M.S.,Moore, J.P.,Ward, A.B.,Wilson, I.A.,Sanders, R.W.,Burton, D.R. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex. Proc.Natl.Acad.Sci.USA, 111:17624-17629, 2014 Cited by PubMed: 25422458DOI: 10.1073/pnas.1415789111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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