3U1S

Crystal structure of human Fab PGT145, a broadly reactive and potent HIV-1 neutralizing antibody

Summary for 3U1S

• Entry DOI: 10.2210/pdb3u1s/pdb
• Descriptor: Fab PGT145 Light chain, Fab PGT145 Heavy chain, SULFATE ION, ... (5 entities in total)
• Functional Keywords: igg, broadly neutralizing antibody, hiv-1 gp120, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 55672.10

Authors

Julien, J.-P.,Diwanji, D.,Burton, D.R.,Wilson, I.A. (deposition date: 2011-09-30, release date: 2011-12-07, Last modification date: 2023-12-06)

• Primary citation: McLellan, J.S.,Pancera, M.,Carrico, C.,Gorman, J.,Julien, J.P.,Khayat, R.,Louder, R.,Pejchal, R.,Sastry, M.,Dai, K.,O'Dell, S.,Patel, N.,Shahzad-Ul-Hussan, S.,Yang, Y.,Zhang, B.,Zhou, T.,Zhu, J.,Boyington, J.C.,Chuang, G.Y.,Diwanji, D.,Georgiev, I.,Do Kwon, Y.,Lee, D.,Louder, M.K.,Moquin, S.,Schmidt, S.D.,Yang, Z.Y.,Bonsignori, M.,Crump, J.A.,Kapiga, S.H.,Sam, N.E.,Haynes, B.F.,Burton, D.R.,Koff, W.C.,Walker, L.M.,Phogat, S.,Wyatt, R.,Orwenyo, J.,Wang, L.X.,Arthos, J.,Bewley, C.A.,Mascola, J.R.,Nabel, G.J.,Schief, W.R.,Ward, A.B.,Wilson, I.A.,Kwong, P.D.; Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.; Nature, 480:336-343, 2011; PubMed: 22113616; DOI: 10.1038/nature10696

Experimental method

X-RAY DIFFRACTION (2.3 Å)