4RPL

Crystal structure of Micobacterium tuberculosis UDP-Galactopyranose mutase in complex with tetrafluorinated substrate analog UDP-F4-Galp

4RPL の概要

• エントリーDOI: 10.2210/pdb4rpl/pdb
• 関連するPDBエントリー: 1V0J 4RPG 4RPH 4RPJ 4RPK
• 分子名称: UDP-galactopyranose mutase, FLAVIN-ADENINE DINUCLEOTIDE, [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,5S,6R)-3,3,4,4-tetrafluoro-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name), ... (4 entities in total)
• 機能のキーワード: udp-galactopyranose mutase, mtugm, flavoenzyme, fad, isomerase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 141960.49

構造登録者

Van Straaten, K.E.,Sanders, D.A.R. (登録日: 2014-10-30, 公開日: 2015-01-21, 最終更新日: 2023-09-20)

• 主引用文献: van Straaten, K.E.,Kuttiyatveetil, J.R.,Sevrain, C.M.,Villaume, S.A.,Jimenez-Barbero, J.,Linclau, B.,Vincent, S.P.,Sanders, D.A.; Structural Basis of Ligand Binding to UDP-Galactopyranose Mutase from Mycobacterium tuberculosis Using Substrate and Tetrafluorinated Substrate Analogues.; J.Am.Chem.Soc., 137:1230-1244, 2015; PubMed: 25562380; DOI: 10.1021/ja511204p

実験手法

X-RAY DIFFRACTION (2.2499 Å)