4RMR
Crystal structure of the D38N Beta-2 Microglobulin mutant
Summary for 4RMR
Entry DOI | 10.2210/pdb4rmr/pdb |
Related | 2YXF 4FXL 4RMQ 4RMS 4RMT 4RMU 4RMV 4RMW |
Descriptor | Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ACETATE ION, ... (4 entities in total) |
Functional Keywords | immunoglobin, beta-sandwitch, amyloidosis, pathologic mutation, genetic disease, mhc class i, immune system |
Biological source | Homo sapiens (human) |
Cellular location | Secreted : P61769 |
Total number of polymer chains | 1 |
Total formula weight | 12043.54 |
Authors | de Rosa, M.,Bolognesi, M.,Ricagno, S. (deposition date: 2014-10-22, release date: 2015-11-18, Last modification date: 2023-09-20) |
Primary citation | de Rosa, M.,Barbiroli, A.,Giorgetti, S.,Mangione, P.P.,Bolognesi, M.,Ricagno, S. Decoding the Structural Bases of D76N 2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis. Plos One, 10:e0144061-e0144061, 2015 Cited by PubMed: 26625273DOI: 10.1371/journal.pone.0144061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.529 Å) |
Structure validation
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