4RMG

Human Sirt2 in complex with SirReal2 and NAD+

Summary for 4RMG

• Entry DOI: 10.2210/pdb4rmg/pdb
• Related: 4RMH 4RMI 4RMJ
• Descriptor: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, 2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide, ... (5 entities in total)
• Functional Keywords: hydrolase-hydrolase inbititor complex, hydrolase/hydrolase inbititor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus. Isoform 1: Cytoplasm . Isoform 2: Cytoplasm . Isoform 5: Cytoplasm : Q8IXJ6
• Total number of polymer chains: 1
• Total formula weight: 35566.11

Authors

Rumpf, T.,Schiedel, M.,Karaman, B.,Roessler, C.,North, B.J.,Lehotzky, A.,Olah, J.,Ladwein, K.I.,Schmidtkunz, K.,Gajer, M.,Pannek, M.,Steegborn, C.,Sinclair, D.A.,Gerhardt, S.,Ovadi, J.,Schutkowski, M.,Sippl, W.,Einsle, O.,Jung, M. (deposition date: 2014-10-21, release date: 2015-02-25, Last modification date: 2024-02-28)

• Primary citation: Rumpf, T.,Schiedel, M.,Karaman, B.,Roessler, C.,North, B.J.,Lehotzky, A.,Olah, J.,Ladwein, K.I.,Schmidtkunz, K.,Gajer, M.,Pannek, M.,Steegborn, C.,Sinclair, D.A.,Gerhardt, S.,Ovadi, J.,Schutkowski, M.,Sippl, W.,Einsle, O.,Jung, M.; Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.; Nat Commun, 6:6263-6263, 2015; PubMed: 25672491; DOI: 10.1038/ncomms7263

Experimental method

X-RAY DIFFRACTION (1.88 Å)