4RMG
Human Sirt2 in complex with SirReal2 and NAD+
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 401 |
| Chain | Residue |
| A | CYS195 |
| A | CYS200 |
| A | CYS221 |
| A | CYS224 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 3TE A 402 |
| Chain | Residue |
| A | TYR139 |
| A | PRO140 |
| A | ASP170 |
| A | PHE190 |
| A | ILE232 |
| A | VAL233 |
| A | PHE234 |
| A | MET299 |
| A | HOH540 |
| A | PHE96 |
| A | ILE118 |
| A | PHE119 |
| A | PHE131 |
| A | ALA135 |
| site_id | AC3 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NAD A 403 |
| Chain | Residue |
| A | GLY84 |
| A | ALA85 |
| A | GLY86 |
| A | THR89 |
| A | ILE93 |
| A | PRO94 |
| A | ASP95 |
| A | PHE96 |
| A | GLN167 |
| A | ASN168 |
| A | ILE169 |
| A | ASP170 |
| A | HIS187 |
| A | GLY261 |
| A | THR262 |
| A | SER263 |
| A | ASN286 |
| A | LYS287 |
| A | GLU288 |
| A | MET299 |
| A | GLY322 |
| A | GLU323 |
| A | CYS324 |
| A | HOH501 |
| A | HOH502 |
| A | HOH558 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 13 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25672491","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RMG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11427894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23454361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24389023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25672491","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25704306","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R8M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q5RJQ4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
