4RMG
Human Sirt2 in complex with SirReal2 and NAD+
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 401 |
Chain | Residue |
A | CYS195 |
A | CYS200 |
A | CYS221 |
A | CYS224 |
site_id | AC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 3TE A 402 |
Chain | Residue |
A | TYR139 |
A | PRO140 |
A | ASP170 |
A | PHE190 |
A | ILE232 |
A | VAL233 |
A | PHE234 |
A | MET299 |
A | HOH540 |
A | PHE96 |
A | ILE118 |
A | PHE119 |
A | PHE131 |
A | ALA135 |
site_id | AC3 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE NAD A 403 |
Chain | Residue |
A | GLY84 |
A | ALA85 |
A | GLY86 |
A | THR89 |
A | ILE93 |
A | PRO94 |
A | ASP95 |
A | PHE96 |
A | GLN167 |
A | ASN168 |
A | ILE169 |
A | ASP170 |
A | HIS187 |
A | GLY261 |
A | THR262 |
A | SER263 |
A | ASN286 |
A | LYS287 |
A | GLU288 |
A | MET299 |
A | GLY322 |
A | GLU323 |
A | CYS324 |
A | HOH501 |
A | HOH502 |
A | HOH558 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236 |
Chain | Residue | Details |
A | HIS187 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25672491, ECO:0007744|PDB:4RMG |
Chain | Residue | Details |
A | ALA85 | |
A | ASP95 | |
A | GLN167 | |
A | THR262 | |
A | ASN286 | |
A | CYS324 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:11427894, ECO:0000269|PubMed:23454361, ECO:0000269|PubMed:24389023, ECO:0000269|PubMed:25672491, ECO:0000269|PubMed:25704306, ECO:0007744|PDB:4R8M |
Chain | Residue | Details |
A | CYS195 | |
A | CYS200 | |
A | CYS221 | |
A | CYS224 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q5RJQ4 |
Chain | Residue | Details |
A | SER100 | |
A | SER207 |