4RMF

Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target

4RMF の概要

• エントリーDOI: 10.2210/pdb4rmf/pdb
• 分子名称: Aspartate--tRNA(Asp/Asn) ligase, 2,2-bis(hydroxymethyl)propane-1,3-diol, FORMIC ACID, ... (4 entities in total)
• 機能のキーワード: alpha and beta proteins, trna synthetase, trna, ligase
• 由来する生物種: Mycobacterium smegmatis
• 細胞内の位置: Cytoplasm : A0QWN3
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 66711.91

構造登録者

Cox, J.A.G.,Gurcha, S.S.,Veeraraghavan, U.,Besra, G.S.,Futterer, K. (登録日: 2014-10-21, 公開日: 2014-11-19, 最終更新日: 2023-09-20)

• 主引用文献: Gurcha, S.S.,Usha, V.,Cox, J.A.,Futterer, K.,Abrahams, K.A.,Bhatt, A.,Alderwick, L.J.,Reynolds, R.C.,Loman, N.J.,Nataraj, V.,Alemparte, C.,Barros, D.,Lloyd, A.J.,Ballell, L.,Hobrath, J.V.,Besra, G.S.; Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target.; Plos One, 9:e113568-e113568, 2014; PubMed: 25409504; DOI: 10.1371/journal.pone.0113568

実験手法

X-RAY DIFFRACTION (2.4 Å)