4RIW

Crystal structure of an EGFR/HER3 kinase domain heterodimer

Summary for 4RIW

Entry DOI	10.2210/pdb4riw/pdb
Related	4RIX 4RIY
Descriptor	Receptor tyrosine-protein kinase erbB-3, Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
Functional Keywords	receptor tyrosine kinase, pseudokinase, kinase, atp binding, membrane, transferase
Biological source	Homo sapiens (human) More
Cellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P21860 Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	4
Total formula weight	153278.75
Authors	Littlefield, P.,Jura, N. (deposition date: 2014-10-07, release date: 2014-12-10, Last modification date: 2023-09-20)
Primary citation	Littlefield, P.,Liu, L.,Mysore, V.,Shan, Y.,Shaw, D.E.,Jura, N. Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations. Sci.Signal., 7:ra114-ra114, 2014 Cited by PubMed: 25468994 DOI: 10.1126/scisignal.2005786 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation