4RHY

Crystal structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease

4RHY の概要

• エントリーDOI: 10.2210/pdb4rhy/pdb
• 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, [2-({2-[bis(2-phosphonoethyl)amino]ethyl}[2-(6-oxo-3,6-dihydro-9H-purin-9-yl)ethyl]amino)ethyl]phosphonic acid, ... (4 entities in total)
• 機能のキーワード: 6-oxopurine phosphoribosyltransferase, cytoplasmic, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 90943.50

構造登録者

Eng, W.S.,Hockova, D.,Spacek, P.,West, N.P.,Woods, K.,Naesens, L.M.J.,Keough, D.T.,Guddat, L.W. (登録日: 2014-10-03, 公開日: 2015-05-20, 最終更新日: 2024-02-28)

• 主引用文献: Eng, W.S.,Hockova, D.,Spacek, P.,Janeba, Z.,West, N.P.,Woods, K.,Naesens, L.M.,Keough, D.T.,Guddat, L.W.; First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.; J.Med.Chem., 58:4822-4838, 2015; PubMed: 25915781; DOI: 10.1021/acs.jmedchem.5b00611

実験手法

X-RAY DIFFRACTION (2.3196 Å)