4RF0
Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease in complex with ubiquitin (space group P6522)
Summary for 4RF0
Entry DOI | 10.2210/pdb4rf0/pdb |
Related | 4REZ 4RF1 |
Descriptor | ORF1ab protein, Ubiquitin-60S ribosomal protein L40, ZINC ION, ... (6 entities in total) |
Functional Keywords | zinc ribbon, deubiquitinase, papain-like protease, protein binding |
Biological source | Human betacoronavirus 2c Jordan-N3/2012 More |
Cellular location | Host cytoplasm, host perinuclear region . Host membrane ; Multi-pass membrane protein : M4STU1 Ubiquitin: Cytoplasm . 60S ribosomal protein L40: Cytoplasm : P62987 |
Total number of polymer chains | 2 |
Total formula weight | 45555.33 |
Authors | Bailey-Elkin, B.A.,Johnson, G.G.,Mark, B.L. (deposition date: 2014-09-24, release date: 2014-10-22, Last modification date: 2015-01-14) |
Primary citation | Bailey-Elkin, B.A.,Knaap, R.C.,Johnson, G.G.,Dalebout, T.J.,Ninaber, D.K.,van Kasteren, P.B.,Bredenbeek, P.J.,Snijder, E.J.,Kikkert, M.,Mark, B.L. Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression. J.Biol.Chem., 289:34667-34682, 2014 Cited by PubMed: 25320088DOI: 10.1074/jbc.M114.609644 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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