4RF0

Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease in complex with ubiquitin (space group P6522)

4RF0 の概要

• エントリーDOI: 10.2210/pdb4rf0/pdb
• 関連するPDBエントリー: 4REZ 4RF1
• 分子名称: ORF1ab protein, Ubiquitin-60S ribosomal protein L40, ZINC ION, ... (6 entities in total)
• 機能のキーワード: zinc ribbon, deubiquitinase, papain-like protease, protein binding
• 由来する生物種: Human betacoronavirus 2c Jordan-N3/2012; 詳細
• 細胞内の位置: Host cytoplasm, host perinuclear region . Host membrane ; Multi-pass membrane protein : M4STU1; Ubiquitin: Cytoplasm . 60S ribosomal protein L40: Cytoplasm : P62987
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 45555.33

構造登録者

Bailey-Elkin, B.A.,Johnson, G.G.,Mark, B.L. (登録日: 2014-09-24, 公開日: 2014-10-22, 最終更新日: 2015-01-14)

• 主引用文献: Bailey-Elkin, B.A.,Knaap, R.C.,Johnson, G.G.,Dalebout, T.J.,Ninaber, D.K.,van Kasteren, P.B.,Bredenbeek, P.J.,Snijder, E.J.,Kikkert, M.,Mark, B.L.; Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression.; J.Biol.Chem., 289:34667-34682, 2014; PubMed: 25320088; DOI: 10.1074/jbc.M114.609644

実験手法

X-RAY DIFFRACTION (2.8 Å)