4RE6

Acylaminoacyl peptidase complexed with a chloromethylketone inhibitor

4RE6 の概要

• エントリーDOI: 10.2210/pdb4re6/pdb
• 関連するPDBエントリー: 4RE5
• 関連するBIRD辞書のPRD_ID: PRD_001053
• 分子名称: Acylamino-acid-releasing enzyme, N-[(benzyloxy)carbonyl]glycyl-N-[(2S,3R)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]glycinamide, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: beta-propeller, alpha-beta-hydrolase fold, chloromethyl-ketone inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Aeropyrum pernix
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 253542.75

構造登録者

Menyhard, D.K.,Orgovan, Z.,Szeltner, Z.,Szamosi, I.,Harmat, V. (登録日: 2014-09-22, 公開日: 2015-01-28, 最終更新日: 2023-09-20)

• 主引用文献: Menyhard, D.K.,Orgovan, Z.,Szeltner, Z.,Szamosi, I.,Harmat, V.; Catalytically distinct states captured in a crystal lattice: the substrate-bound and scavenger states of acylaminoacyl peptidase and their implications for functionality.; Acta Crystallogr.,Sect.D, 71:461-472, 2015; PubMed: 25760596; DOI: 10.1107/S1399004714026819

実験手法

X-RAY DIFFRACTION (2.55 Å)