4RE6

Acylaminoacyl peptidase complexed with a chloromethylketone inhibitor

Summary for 4RE6

Entry DOI	10.2210/pdb4re6/pdb
Related	4RE5
Related PRD ID	PRD_001053
Descriptor	Acylamino-acid-releasing enzyme, N-[(benzyloxy)carbonyl]glycyl-N-[(2S,3R)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]glycinamide, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	beta-propeller, alpha-beta-hydrolase fold, chloromethyl-ketone inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Aeropyrum pernix
Total number of polymer chains	4
Total formula weight	253542.75
Authors	Menyhard, D.K.,Orgovan, Z.,Szeltner, Z.,Szamosi, I.,Harmat, V. (deposition date: 2014-09-22, release date: 2015-01-28, Last modification date: 2023-09-20)
Primary citation	Menyhard, D.K.,Orgovan, Z.,Szeltner, Z.,Szamosi, I.,Harmat, V. Catalytically distinct states captured in a crystal lattice: the substrate-bound and scavenger states of acylaminoacyl peptidase and their implications for functionality. Acta Crystallogr.,Sect.D, 71:461-472, 2015 Cited by PubMed: 25760596 DOI: 10.1107/S1399004714026819 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation