4RE6

Acylaminoacyl peptidase complexed with a chloromethylketone inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0008242	molecular_function	omega peptidase activity
A	0016787	molecular_function	hydrolase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity
B	0008242	molecular_function	omega peptidase activity
B	0016787	molecular_function	hydrolase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0008236	molecular_function	serine-type peptidase activity
C	0008242	molecular_function	omega peptidase activity
C	0016787	molecular_function	hydrolase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0008236	molecular_function	serine-type peptidase activity
D	0008242	molecular_function	omega peptidase activity
D	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE Y3A A 601

Chain	Residue
A	GLY369
A	SER445
A	TYR446
A	PHE485
A	PHE488
A	ARG526
A	HIS556
A	HOH752

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 602

Chain	Residue
A	ARG345

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 601

Chain	Residue
B	ALA388

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 602

Chain	Residue
B	GLN282
B	SER301
B	THR304

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site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE Y3A C 601

Chain	Residue
C	PHE153
C	GLY368
C	GLY369
C	SER445
C	PHE485
C	PHE488
C	ARG526
C	HIS556
C	HOH711
C	HOH738

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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