4RE5

Acylaminoacyl peptidase complexed with a chloromethylketone inhibitor

Summary for 4RE5

• Entry DOI: 10.2210/pdb4re5/pdb
• Related: 4RE6
• Related PRD ID: PRD_001053
• Descriptor: Acylamino-acid-releasing enzyme, N-[(benzyloxy)carbonyl]glycyl-N-[(2S,3R)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]glycinamide, ACETATE ION, ... (6 entities in total)
• Functional Keywords: beta-propeller, alpha-beta-hydrolase fold, chloromethyl-ketone inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Aeropyrum pernix
• Total number of polymer chains: 2
• Total formula weight: 127561.94

Authors

Menyhard, D.K.,Orgovan, Z.,Szeltner, Z.,Szamosi, I.,Harmat, V. (deposition date: 2014-09-22, release date: 2015-01-28, Last modification date: 2023-09-20)

• Primary citation: Menyhard, D.K.,Orgovan, Z.,Szeltner, Z.,Szamosi, I.,Harmat, V.; Catalytically distinct states captured in a crystal lattice: the substrate-bound and scavenger states of acylaminoacyl peptidase and their implications for functionality.; Acta Crystallogr.,Sect.D, 71:461-472, 2015; PubMed: 25760596; DOI: 10.1107/S1399004714026819

Experimental method

X-RAY DIFFRACTION (1.9 Å)