4RBW

Crystal structure of human alpha-defensin 5, HD5 (Thr7Arg Glu21Arg mutant)

Summary for 4RBW

Entry DOI	10.2210/pdb4rbw/pdb
Related	1ZMP 4E82 4E83 4E86 4RBX
Descriptor	Defensin-5, SULFATE ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	mutant t7r e21r-hd5, beta-sheet, antimicrobial peptide, paneth cells defensin, human alpha-defensin, antimicrobial protein
Biological source	Homo sapiens (human)
Cellular location	Secreted : Q01523
Total number of polymer chains	4
Total formula weight	15649.07
Authors	Pazgier, M.,Gohain, N.,Tolbert, W.D. (deposition date: 2014-09-13, release date: 2015-07-29, Last modification date: 2023-09-20)
Primary citation	Wang, C.,Shen, M.,Gohain, N.,Tolbert, W.D.,Chen, F.,Zhang, N.,Yang, K.,Wang, A.,Su, Y.,Cheng, T.,Zhao, J.,Pazgier, M.,Wang, J. Design of a potent antibiotic peptide based on the active region of human defensin 5. J.Med.Chem., 58:3083-3093, 2015 Cited by PubMed: 25782105 DOI: 10.1021/jm501824a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation