4RA0
An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis
Summary for 4RA0
Entry DOI | 10.2210/pdb4ra0/pdb |
Descriptor | Growth arrest-specific protein 6, Tyrosine-protein kinase receptor UFO, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | axl, gas6, cancer, metastasis, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 132492.68 |
Authors | Kariolis, M.S.,Kapur, S.,Mathews, I.I.,Cochran, J.R. (deposition date: 2014-09-09, release date: 2014-09-24, Last modification date: 2023-09-20) |
Primary citation | Kariolis, M.S.,Miao, Y.R.,Jones, D.S.,Kapur, S.,Mathews, I.I.,Giaccia, A.J.,Cochran, J.R. An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis. Nat.Chem.Biol., 10:977-983, 2014 Cited by PubMed: 25242553DOI: 10.1038/nchembio.1636 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.07 Å) |
Structure validation
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